Recent Publications

  1. Lu Liu, Ayaka Inoki, Kelly Fan, Fengbiao Mao, Guojun Shi, Xi Jin, Meiling Zhao, Gina Ney, Shengyi Sun, Yali Dou, Ken Inoki, Ling Qi, Qing Li: Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity. Pre-print @ biorxiv, July 21st, 2019, Under review @ Nature cell Biology. 
  2. Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, and Li Q: Adaptive ER stress signaling via IRE1α/XBP1 preserves self-renewal of hematopoietic and pre-leukemic stem cells. Nature Cell Biology 2019 21(3): 328 (Featured on News $ Views, Nature Cell Biology same issue)
  3. Choi HK, Yuan H, Fang F, Wei X, Liu L, Li Q, Guan J, and Liu F: Tsc1 regulates the balance between osteoblast and adipocyte differentiation through autophagy/Notch1/β-catenin cascade. Journal of Bone and Mineral Research 2018 33(11):  2021-2034
  4. Jin X, Qin T, Zhao M, Bailey N, Liu L, Yang K, Ng V, Higashimoto T, Coolon R, Ney G, Figueroa ME, and Li Q: N-RasG12D and Tet2 Haploinsufficiency Collaborate to Dysregulate Hematopoietic Stem and Progenitor Cells to Promote Leukemogenesis. Blood Advances 2018 2(11): 1259-1271
  5. Chapple RH, Hu T, Tseng Y, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, and Nakada D: ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response. Elife. 2018 Feb 16;7. pii: e31159. doi: 10.7554/eLife.31159.
  6. Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Amy Young, Jennifer A. LaCap, Lisa Crocker, Saurabh Asthana, Elizabeth M. Davis, Jin Xu, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, and Shannon K: KRAS Allelic Imbalance Enhances Fitness and Modulates MEK Dependence In KRAS Mutant Cancers. Cell 168(5):817-829. 2017
  7. Fenouille N, Bassil CF, Ben-Sahra L, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, and Stegmaier K: The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nature Medicine 23(3):301-313. 2017
  8. Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q, Preclinical efficacy of MEK inhibition in Nras mutant acute myeloid leukemia. Blood 2014; 124(26):3947-55
  9. Dail M, Wong J, Lawrence J, O'Connor D, Nakitandwe J, Chen SC, Xu J, Lee LB, Akagi K, Li Q, Aster JC, Pear WS, Downing JR, Sampath D, Shannon K: Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia. Nature 513(7519): 512-6, 2014. PM25043004
  10. Li Q*(co-corresponding author), Bohin N, Wen T, Ng V, Magee J, Chen SC, Shannon KM, Morrison SJ*. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature 2013; 504(7478):143-7 (featured on “News & Views” on the same issue of Nature, and by Burgess DJ, Nature Review Cancer 2014 Jan;14(1):5).
  11. Xu J , Haigis KM, McNerney M, Li Q, Davis E, Dr. Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon KM. Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation. Cancer Discovery 2013; 3(9):993-1001. Epub Jun 3 2013.
  12. Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood 2012; 119(4):1032-5
  13. Shannon KM and Li Q. Oncogenic Ras scales the ALPS Blood 2011; 117:2747-2748
  14. Li Q, Haigis K, McDaniel A, Harding-Theobald E, Wong J, Kogan S, AkagiK, Wolff L, Jacks T, and Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood 2011; 117 (6): 2022-2032
  15. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.Proc Natl Acad Sci USA. 2010;107(11):5106-11.
  16. Lauchle JO, Kim D. Le DT, Akagi K, Gorman M, Krisman K, Crone M, Bonifas JM, Li Q, Tran M, Przybranowski S, Diaz-Flores E, Peterson A, Knab B, Kogan SC, Roose J, Copeland N, Jenkins N, Parada LF, Wolff L, Leopold J, Shannon. Response and resistance to MEK inhibition in myeloid malignancies initiated by hyperactive Ras. Nature 2009;  461(7262):411-4

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/sites/myncbi/qing.li.2/bibliography/47459895/public/?sort=date&direction=ascending